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Fri Oct 10

• Seed: A New State of Mind: "Olds and Milner quickly discovered that too much pleasure can be fatal. After they ran a small current into the wire, so that the NAcc was continually excited, the scientists noticed that the rodents lost interest in everything else." "What wasn't yet clear was that dopamine is also a profoundly important source of information. It doesn't merely let us take pleasure in the world; it allows us to understand the world." "The crucial feature of these dopamine neurons, say Montague and Dayan, is that they are more concerned with predicting rewards than with the rewards themselves.&qu ot; "That 9;s what makes ideas so powerful: No matter how esoteric or ethereal they get, they are ultimately fed back into the same system that makes us want sex and sugar."

Thu Oct 9

• Do You Feed or Devour Your Lover? | Reuniting
• Involvement of Amygdala Dopamine and Nucleus Accum...[Neuro psychopharmaco logy. 2008] - PubMed Result: amygdala dopamine receptors and accumbens nmda receptors are involved in ethanol-induce d conditioned effects
• An Animal Model of a Behavioral Intervention for Depression:Neu ron -- Pollak et al.
• ACh/Dopamine Crosstalk in Motor Control and Reward: A Crucial Role for ?6-Containing Nicotinic Receptors?: Neuron -- Calabresi and Di Filippo

Wed Oct 8

• Reuniting | Healing with Sexual Relationships
• Transient and selective overexpression of D2 receptors in the striatum causes persistent deficits in conditional associative learning ? PNAS: The authors developed operant tasks to assay two executive functions, conditional associative learning (CAL) and nonspatial working memory to analyze behavioral phenotype of genetic mice with the increase in striatal D2 receptor.

Tue Oct 7

• Adaptive binning in the retina: Binning increases signal (in light-limited systems, eg. seeing at night) by increasing optical input area and by reducing single element noise (ie. noise at different photoreceptors should be independent) at the cost of resolution. So, the retina activates photoreceptor binning at night to boost low-light signals and deactivates it during the day to increase resolution. The dopamine comes from cells in the interplexiform layer, whose dopamine release is itself governed by melatonin projections.

Mon Oct 6

• Adenylyl cyclase-5 activity in the nucleus accumbens regulates anxiety-relate d behavior. Journal of Neurochemistry (2008): Kyoung-Shim Kim*, Ko-Woon Lee*, In-Sun Baek*, Chae-Moon Lim?, Vaishnav Krishnan?, Ja-Kyeong Lee?, Eric J. Nestler?,§ and Pyung-Lim Han* *Division of Nano Sciences and Brain Disease Research Institute, Ewha Womans University, Seoul, Korea ?Department of Anatomy, Inha University School of Medicine, Inchon, Korea ?Departments of Psychiatry and Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas, USA §Department of Neuroscience, Mount Sinai School of Medicine, New York, USA

Wed Oct 1

• Learn.Genetics

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